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It promotes neutrophil chemotaxis and degranulation leading to local inflammation in damaged tissues 37
Because the peptide typically peaks and declines within a few hours, spacing injections at least 24 hours apart tends to reduce stacking of acute side effects like nausea, flushing, and blood pressure swings
For instance, Tat mediates astrocyte senescence and the production of ROS and pro-inflammatory cytokines, while gp120 and methamphetamine induce apoptosis [165, 166]
Second, it is able to induce the combination of ,-unsaturated ketones and GSH through the nucleophilic addition reaction, depleting GSH and reducing the amount of GSH available to combine with chemotherapeutic agents, thus producing an overall GST-inhibitory effect by sensitizing a cell to chemotherapeutic agents
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