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Among individual agents, liraglutide demonstrated a consistent mortality benefit in individuals with T2DM (Class IV

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However, with the progression of research, it has become evident that GLP-1R is broadly distributed across various organs and tissues, including but not limited to the brain, heart, kidneys, intestines, eyes, and the vascular system (Meier, 2012

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Moreover, 14 mg oral semaglutide reduced body fat mass and energy intake of T2D patients within 12 weeks and increased satiety in people eating high-calorie breakfasts

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