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For example, inflammatory factors and chemokines in synovial fluid can attract and activate immune cells, promoting their differentiation and proliferation, which intensifies inflammatory responses and cartilage damage ( Therefore, the differentiation of immune cells in OA has both damaging and protective effects, acting as a double-edged sword

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The first GLP-1 analog (exenatide) was derived from the surprising source of Gila monster venom and approved in 2005 ( [3] ) ( [4] ), opening a new era of incretin mimetic therapy