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Sie wirken aufgrund ihrer strukturellen hnlichkeit mit dem Peptidhormon GLP-1 (Glucagon-like peptide 1)

A subsequent investigation corroborated similar findings

Of note, the confidence intervals for glycemic reduction in PIONEER 2 and 4 excluded the value of 0.3% which suggests that the choice of the non-inferiority margin likely would not have impacted conclusions for these comparisons