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For the comparative evidence base, see the national glutathione treatment and skin whitening treatment hubs
Experimental studies suggest possible effects involving: Nitric oxide signaling Blood vessel formation (angiogenesis) Cellular communication pathways Fibroblast migration Collagen organization Tissue remodeling after injury Fibroblasts are specialized cells responsible for producing collagen and rebuilding damaged connective tissue
However, the cytotoxic effects of MTX are not limited to cancer cells and can also affect many normal tissues including the brain (Behairy et al
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