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Some of the critical enzymes in HDL include glutathione peroxidase 1 (GPx), paraoxonase 1 (PON1), and platelet activating factor acetylhydrolase (PAF-AH, also called lipoprotein-associated phospholipase A 2 , Lp-PLA 2 )
The Absorption Problem with Oral GSH The intestinal lumen contains abundant gamma-glutamyl transferase (GGT), an enzyme that cleaves the glutamate residue from glutathione, breaking it into its constituent amino acids before systemic absorption can occur
Tolerability and Side Effects Both forms may cause nausea, vomiting, reduced appetite, or gastrointestinal discomfort, particularly during dose escalation
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