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Subsequently, prostaglandin and thromboxane generated by cyclooxygenase as well as leukotrienes generated by lipoxygenase from arachidonate (20:4n-6) function as lipid mediators

What your describing is not uncommon because methylation process is so complex & you may be deficient in other co-factors, such as B6, B2, Same, B12, etc Too much 5MTHF can drive overmethylation or dampen glutathione production and lead to agitation, irritability

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If you take a blood thinner or platelet-affecting medication, your healthcare provider may recommend Tylenol instead of an NSAID (such as aspirin, ibuprofen/Advil, or naproxen/Aleve) for minor pain or fever, since NSAIDs have blood-thinning effects and can irritate the stomach