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4a, bottom and Supplementary Data 2), suggesting that MZB rely on glycolysis rather than oxidative metabolism at steady-state
This is particularly valuable given that declining estrogen levels during menopause increase insulin resistance risk
NICE guideline NG28 recognises both classes within type 2 diabetes management pathways, typically considered when dual therapy fails to achieve glycaemic targets or additional organ protection is needed
Orforglipron is an oral, small-molecule GLP-1 receptor agonist that was administered once daily in tablet form in clinical trials
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