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Some research suggests that chronic high-dose L-carnitine supplementation may increase TMAO levels via gut bacteria metabolism, and elevated TMAO has been associated with increased cardiovascular risk in observational studies
Skopelitou et al., 2012a,b)
In addition, elevated expression of Idh2 and Ggt6 further supports increased NADPH production and glutathione turnover, essential for maintaining the reduced state of glutathione
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