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In summary, these data support a gut-joint axis in RA, which is based on zonulin-mediated impairment of intestinal barrier function and which is drugable by the zonulin antagonist larazotide
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These patients are often recommended to receive 1 mg of oral vitamin B12 daily indefinitely, but intramuscular injections may be necessary if oral supplementation is insufficient Mahawar2018Langan2017
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