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If glutathione is depleted, these reactive intermediates cause severe oxidative damage to the liver's cellular DNA and proteins
Physiologically, patients with asthma frequently experience disruptions in their melatonin levels, namely a delayed acrophase in peak serum concentrations, as well as in the amount of GSH produced in the lung ( In clinical practice, melatonin is often prescribed at a dose of 2mg for the average (70kg) human adult (69)
The investigators note that the childrens response was more variable than the young adult cohort, possibly reflecting developmental differences or dosing considerations
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