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Severe abdominal pain, particularly if accompanied by fever, could indicate pancreatitisa rare but serious adverse effect associated with GLP-1 receptor agonists

Unintended consequences in the form of not just weight gain but also increased risk of cardiovascular disease, diabetes mellitus type 2, hypertension and metabolic syndrome, all vigorously disputed, of course (see some examples in references 1, 2), which brings us to the glaring caveat we need to keep front and center when considering the science about artificial sweeteners

In the STEP 1 trial, up to 44% participants on semaglutide reported nausea, and 24% reported nausea

This modification, by competing with ubiquitination, inhibits SLC7A11 degradation and maintains its stable expression on the membrane