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The core PRC2 complex consists of EZH1/2, EED164, SUZ12, and RBBP4/7, and can associate with several PRC2 accessory proteins, such as PCL1-PCL3, JARID2, AEBP2, EPOP, and LCOR (Margueron et al., 2009
Continuous year-round use is pharmacologically feasible MT2 does not induce receptor downregulation that would reduce efficacy over time, and there is no physiological basis for mandatory cycling as seen with some hormone analogs
I will assess the need for further testing, such as other imaging or blood tests
For weight loss specifically, this is not a close comparison
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