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If using cooling elements, ensure there is a barrier (such as fabric) between the ice pack and the medication pen
Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig
Think of it as a repair signal that may be layered on top of standard care, not a replacement
Classes 2 and 3 represent 90% of the cases
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