depression and tirzepatide Psychiatric Safety of Tirzepatide: 3 Surprising Findings from a Landmark Post Hoc Analysis of SURMOUNT Tirzepatide Weight-Loss Therapy Not Linked

This makes it particularly useful for those reducing meat intake or following plant-based diets where natural L-Carnitine consumption may be lower

However, the clinical relevance of such stratification for predicting treatment response has also been questioned, as it assumes homogeneity within each cluster 8,11,12,13,14

The SELECT trial, published in The Lancet (October 22, 2025), provides a landmark analysis confirming that the cardioprotective benefits of semaglutide extend beyond weight loss alone. The SELECT Trial: Study Overview The SELECT trial (NCT03574597) enrolled 17,604 participants aged 45 years and above across 41 countries and 804 sites

The most common side effect is mild injection site irritation