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The medication's effect on gastric emptying can exacerbate pre-existing gastroesophageal reflux disease (GERD), potentially causing retrosternal burning or pressure that mimics cardiac symptoms

The presence of insulin resistance has been linked to mitochondrial dysfunction, excessive production of reactive oxygen species, and increased a-synuclein aggregation

Once mixed, the solution must be refrigerated at 28C and used within 28 days

Both cross the bloodbrain barrier and have been shown to lower nighttime cortisol by dampening the hypothalamicpituitaryadrenal (HPA) axis, which in turn reduces stressinduced awakenings