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From a timing standpoint, research-style protocols frequently highlight a relatively fast onset : GH pulses are commonly reported to rise within ~3060 minutes after administration, then gradually taper back toward baseline over the next few hours

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Faverzani JL, Hammerschmidt TG, Mescka CP, Guerreiro G, Lopes FF, Delgado CA, de Moura Coelho D, Sitta A, Deon M, Wajner M, Vargas CR (2023) Increased cytokine levels induced by high phenylalanine concentrations in late diagnosis PKU patients compared to early diagnosis: anti-inflammatory effect of L-carnitine