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GLP-1 also helps moderate other hormones related to blood sugar and appetite, including leptin, which signals fullness, and ghrelin, the hunger hormone. Additionally, GLP-1 slows gastric emptying, which sustains a feeling of fullness and decreases the speed at which glucose enters the bloodstream
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Sulfonylureas (such as glipizide, glyburide, and glimepiride) also increase hypoglycemia risk when combined with semaglutide
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