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Cellular senescence and senolytics: the path to the clinic
In 1951, Thorpe was the first to apply hyaluronidase in dermatological surgery [295], When hyaluronidase is used in combination with local anesthetic, the diffusion rate of local anesthetic is proportional to the amount of hyaluronidase injected, which accelerates the onset time of anesthesia and reduces the swelling caused by local infiltration [296]
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