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GIP (Glucose-Dependent Insulinotropic Polypeptide) is another hormone that plays a role in: Insulin secretion Energy balance Fat metabolism Why Combining GIP + GLP-1 Matters Tirzepatides dual agonist action means it targets both pathways simultaneously

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96 Additionally, AMPK activation by reduced ATP levels maintains NADPH through inhibiting NADPH consumption in fatty-acid synthesis and enhancing NADPH production from fatty-acid oxidation instead of PPP to inhibit cell death

The body adapts to the new signaling patterns, and normal function returns