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In the large semaglutide and tirzepatide obesity trials led by Wilding (2021) and Jastreboff (2022), gastrointestinal symptoms were the most common side effects, were generally mild to moderate, clustered around the dose-escalation phase, and eased over time for most people
But intellectual honesty requires me to steelman the other side, because the counterarguments are not trivial
It is likely that the peptide works through several different biochemical pathways and that it has effects and the level of gene transcription [3]
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