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89 Importantly, restoration of hypothalamic autophagy via nutritional interventions such as docosahexaenoic acid-acylated astaxanthin monoester (AST-DHA) supplementation or genetic activation of Atg5 ameliorates obesity and improves glucose metabolism in experimental models, 90 demonstrating that hypothalamic autophagy is not merely correlative but mechanistically regulatory

Notably, several ongoing phase II and phase III clinical trials are examining the effects of exenatide, exendin-4, semaglutide, and two novelty drugsPT320 and NLY01on the progression of PD

Patients who did not stop Ozempic use at any time prior to surgery were at the highest risk for all complications studied

Encourage patients to avoid nonprescription forms of these weight management medications