Although lowering systolic blood pressure to less than 130 mmHg reduces the risk of stroke, it remains unclear whether it reduces the risk of coronary artery disease, cardiovascular mortality or all-cause mortality according to the results from clinical trials of patients with diabetes and hypertension [20, 21]
Therefore, following the step-by-step titration schedule is essential to ensure safety and improve tolerability
Recommended testing schedule Baseline (before starting): Complete metabolic panel, CBC, lipid panel, HbA1c (even if not diabetic), B12, folate, vitamin D, thyroid panel, and fasting insulin
At the ideal storage pH of above 7.0, semaglutide shows maximum stability, but temperature excursions can override even optimal pH conditions