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For the treatment-regimen estimand, the mean body weight reductions from baseline at 72 weeks were 15.0%, 19.5%, and 20.9% in the tirzepatide 5, 10, and 15 mg groups, respectively, versus 3.1% in the placebo group
The clinical implication is that for children showing signs of mitochondrial weakness (low energy, post-exertional fatigue, regression with illness, abnormal organic acids markers, or borderline-low free carnitine on plasma testing), L-carnitine supplementation can be a meaningful adjunct
Each vegetable capsule contains: Acetylcarnitine hydrochloride
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