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In the obese trial cohort, 1 mg moved 24-hour ambulatory heart rate by +0.7 bpm at week 24 the peak of the heart-rate curve, and below the placebo arms +0.8. In a healthy lean Phase 1 group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population
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GLP-1s A Reddit user shared that after initially losing weight on retatrutide, switching to a new vial from a different "light gray" supplier, they noticed their hunger returning and even gained 1.5 kg after a week
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