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"Beyond the obvious body composition perspective, what actually matters is reducing the risk of obesity-related disease and complications, as we prioritized in our 2025 AACE Clinical Practice Algorithm," he says
A Phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023) reported that participants receiving higher doses of retatrutide (up to 12 mg) achieved mean body weight reductions of approximately 1724% over 48 weeks
A TUE should be sought for doses in excess of these limits
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