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It is generally not seen for Tirzepatide or Retatrutide in standard metabolic research, as their long-acting nature makes daily administration unnecessary and potentially counterproductive due to accumulation
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However, if a firm lump resembling the shape of the applicator appears and lasts more than a few weeks, it could be a sign of Paradoxical Adipose Hyperplasia (PAH), a rare but treatable side effect
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