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Safe Use, Dosage, and NHS Guidance on Vitamin B12 Pills The NHS recommends 1.5 mcg daily for adults, but therapeutic doses for deficiency are much higher oral cyanocobalamin 50150 mcg daily for dietary deficiency, or intramuscular hydroxocobalamin 1 mg for absorption-related causes

Several commercial weight loss clinics offer B12 injections as part of their programmes, but these are not evidence-based treatments, and any perceived benefit is likely attributable to other concurrent lifestyle changes