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The condition typically develops gradually, starting as mild stiffness that resolves with warmup, then progressing to persistent pain that limits training capacity

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In cellular models of ALS the RNA processing gets severely impaired upon oxidative stress, in turn causing the mis-localization of TDP-43 and FUS ( Another major factor contributing to the pathophysiological mechanisms in ALS is excitotoxicity, triggered by excessive postsynaptic glutamate receptor stimulation