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A limitation of the present analysis is that we cannot exclude the possibility that other demographic factors that we did not evaluate were influential in the target patient population
The landscape for CKD-protective therapies used in type 2 diabetes is evolving rapidly
When patients experience numbness whilst taking Mounjaro, alternative explanations should be thoroughly explored: Pre-existing diabetic neuropathy many patients prescribed Mounjaro have longstanding type 2 diabetes, a condition frequently complicated by peripheral nerve damage Rapid metabolic changes significant improvements in glycaemic control may temporarily affect nerve function Nutritional factors reduced food intake due to gastrointestinal symptoms or appetite suppression might affect nutrient intake Concurrent medications polypharmacy in diabetes management may include drugs with neurological side effects, particularly metformin which can reduce vitamin B12 levels with long-term use (MHRA Drug Safety Update) Whilst individual case reports exist in patient forums and anecdotal accounts, these do not constitute clinical evidence of causation
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