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24, 2025, in JAMA Internal Medicine followed 308 people taking tirzepatide for 36 weeks
The relationship between diabetes and cognitive impairment involves many aspects, including central insulin signal transduction, nerve fiber damage caused by hyperglycemia, neuritis, oxidative stress, bloodbrain barrier damage, vascular neuropathy, changes in the dopaminergic system, and the effects of advanced glycation end products on metabolism and energy (Figure 1)
Sato, Y., Silina, K., van den Broek, M., Hirahara, K
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