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GIP (glucose-dependent insulinotropic polypeptide) is also a hormone involved in appetite regulation
Within that trial, the body-composition substudy showed that fat mass declined proportionally far more than lean mass, and the ratio of fat-to-lean loss was in line with what has been reported for semaglutide and tirzepatide
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Key Takeaway: Anecdotal reports describe pain reduction on GLP-1s, possibly via the drugs known suppression of inflammatory cytokines, but no randomized trial has confirmed this in lipedema patients
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