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In the blood stream as nicotinic acid, it can cause skin flush and this reaction is actually responsible for the tolerable upper limit (UL) for niacin at 35 mg/d for adults in US (20)
The study looked at the effect of saponins from asparagus being injected into mice for 56 days and saw an improvement in cellular immunity without the high allergic reactions typical in drugs used to prevent secondary tumors
In addition, mitochondrial shrinkage and increased membrane density were observed, indicating that SAL induces ferroptosis and exacerbates neurotoxicity in both in vivo and in vitro PD models
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