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Evidence From Clinical Trials on Cardiovascular Outcomes Phase 2 data (NEJM 2023) showed systolic blood pressure reductions of approximately 46 mmHg and a modest heart rate increase, but no cardiovascular outcome trial exists for retatrutide and definitive conclusions about cardiovascular benefit or risk cannot yet be made

It also explains why antioxidant therapies (vitamins C and E, catalase mimetics, and polypodium leucotomos extract) are being investigated as supportive therapy