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This engagement appears to promote conformational changes in GHS-R1a, triggering G-protein activation, primarily through the Gq/11 subunit
269 GermainARuppertDLevineSMHansonMR
The dual role of COP1 as both an independent E3 ligase and a component of the CRL4 complex suggests that it may act as a molecular switch, toggling between distinct functional modes depending on cellular context
hence, targeting glutamine metabolism may show therapeutic effects in these cancers
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