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Our 2030 estimates contemplate global penetration into the addressable type 2 diabetes and obesity markets of only 8% and 2%, respectively (from about 3% and 0.2% in 2023). Uptake would likely be greater if these drugs could be consumed in oral form rather than injected, adds the report, An oral weight loss agent would likely be well-received in the primary care setting and could alleviate pressure on supply chains

Injection site reactions are localized to a small area around the injection point and typically resolve within days

For instance, ApoE, sharing the brain uptake receptor with SELENOP, appears to be important for the regulation of tight junction integrity at the BBB (Blanchette and Daneman, 2015)