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The framework prioritised semaglutide and tirzepatide as first-line treatments, based on evidence of 15% weight loss and benefits in complications such as cardiovascular disease and sleep apnoea
The minimum recommended gap between cycles is four months
A systematic review found hot flashes and night sweats were common during perimenopause, and a newer study found the rise in hot flushes was especially noticeable in late perimenopause
These medications are prescribed alongside a reduced-calorie diet and increased physical activity to support sustainable weight loss and improved overall health
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