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In combination with metformin immediate-release and rosiglitazone, sitagliptin provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo with metformin immediate-release and rosiglitazone (Table 12) at Week 18
These effects have been confirmed in animal experiments, but not in humans, and the specific mechanism remains unknown
Trainito A, Muscar C, Gugliandolo A, Chiricosta L, Salamone S, Pollastro F, et al
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