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"It's complicated," Heath Schmidt, an addiction researcher and associate professor of psychiatry at the University of Pennsylvania Perelman School of Medicine, tells Yahoo Life

As you move into higher doses, tolerance becomes less frequent because the medication effects are stronger and longer lasting

Since these species of Prevotella produce SCFAs like butyrate, their decrease may affect intestinal barrier function and immune health and thus be involved in the pathogenesis of PD (Hey et al., 2023)