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44 The actions of GIP in vascular endothelial cells are notable for enhancing the intracellular calcium levels and nitric oxide without affecting endothelin-1 production

La enzima dipeptidil peptidasa-4 (DPP-4) y, en menor medida, la endopeptidasa neutra degradan rpidamente el GLP-1 circulante, lo que limita su duracin de accin y representa un desafo para su uso teraputico directo