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Because its effects gradually fade over this period, a 5-week washout period is generally considered for surgical safety
WAT also releases proinflammatory cytokine tumor necrosis factor (TNF)-, which influences hyperinsulinemia in obesity, and proinflammatory cytokine interleukin (IL)-6, which produces free fatty acids (FFAs), causing poor glucose and liver metabolism (Hotamisligil et al
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