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Polycystic ovary syndrome (PCOS) : Approximately 4080% of women with PCOS are overweight or obese
Consistent use is associated with fewer adverse events than intermittent use
Engineered expression systems may not match receptor density or signaling complexity in native tissues
Notably, in the placebo group, greater early weight loss was paradoxically associated with higher subsequent MACE risk, likely reflecting unintentional weight loss or underlying illness
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