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He had been diagnosed with prediabetes for approximately 8 years and was previously treated with metformin
It reliably raises serum B12 levels, resolves megaloblastic anemia, and, when started before irreversible damage, can reverse neurological symptoms
For patients already on venlafaxine at doses 150 mg/day (where NET inhibition becomes clinically relevant), adding an uncharacterized vasopressive modulator creates a monitoring burden that cannot be managed without serial blood pressure measurement
Regarding migraine headache, administration of pyridoxine has decreased headache attack severity and duration in comparison with placebo, with no effect on frequency (72)
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