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GLP-1 is similar to but unlike GIP, actions of GLP-1 are better preserved in type 2 diabetes mellitus (T2DM) patients, which makes it a highly desirable target for drug discovery for T2DM (Sharma and Bhatia, 2020)

Insurance Credentialing Credential with major commercial payers in your market (Blue Cross, Aetna, UnitedHealthcare, Cigna) Apply for Medicare participation if serving patients 65 and older Use obesity-specific diagnosis codes (E66.01, E66.09) and appropriate E&M codes Bill for medical nutrition therapy (MNT) when provided by a credentialed dietitian Prior authorization support is critical for GLP-1 medications

The peptide acts as an agonist at the ghrelin/GHS receptor, stimulates Gq and Go signaling, increases intracellular calcium in somatotrophs, triggers exocytosis of GH-containing vesicles, and may also stimulate GHRH release and reduce somatostatin at the hypothalamic level