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The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery

AOD9604 and 3-AR Knockout Research Research using 3-adrenergic receptor knockout mice established that AOD9604s chronic in vivo lipolytic actions are mediated in part by modulating the expression of 3-AR in adipose tissue a mechanism shared with intact hGH with the restoration of depressed 3-AR RNA levels in obese animals to lean-comparable levels identified as a key pathway of sustained lipolytic sensitisation

We expect this to trend down as visceral fat decreases, since visceral fat is itself a driver of chronic inflammation

Amelia Zofia Michalak, [email protected]