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Molecular pharmacology of the Na+-dependent transport of acidic amino acids in the mammalian central nervous system

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While repurposing of metformin is being expanded to include a variety of pathophysiological disorders due to its pleiotropic modes of action (Foretz et al., 2023a), we aim to specifically examine the current knowledge on metformin-microbiota connection and its associated synergistic and/or detrimental effects in T2D individuals