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BRCA mutations, Lynch syndrome, Li-Fraumeni syndrome, and other hereditary cancer syndromes create environments where additional risk factors deserve careful consideration

Reactive oxygen and nitrogen species in carcinogenesis: implications of oxidative stress on the progression and development of several cancer types

Similarly, inverse agonists of the cannabinoid-1 receptor have demonstrated favorable metabolic and structural outcomes in preclinical models, improving insulin sensitivity and maintaining renal architecture (239, 240)