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We prioritized genes belonging to several biological classes related to kidney function based on: missense variants (either the lead or a proxy variant, 34 genes), DEPICT gene prioritization results (156 genes), significantly colocalized eQTLs in either kidney (4 genes) or non-kidney (187 genes) tissue, or nearby Mendelian kidney-disease genes (Supplementary Tables 12, Supplementary Data 24)
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5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing these measures to age-matched lean animals, while LD switch alone was unable to restore these measures to age-matched controls in the same time frame
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