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SPL UNCLASSIFIED SECTION Data SPL UNCLASSIFIED SECTION Animal Data In pregnant rats given twice weekly subcutaneous doses of 0.02, 0.1, and 0.5 mg/kg tirzepatide (0.03-, 0.07-, and 0.5-fold the MRHD of 15 mg once weekly based on AUC) during organogenesis, increased incidences of external, visceral, and skeletal malformations, increased incidences of visceral and skeletal developmental variations, and decreased fetal weights coincided with pharmacologically-mediated reductions in maternal body weights and food consumption at 0.5 mg/kg

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This is why patients with neurological involvement are often maintained on a more frequent schedule (every 2 months rather than every 3 months)

Administration of BPC-157 has been linked to reduced myocardial tissue damage following experimentally induced infarction, along with improved functional outcomes in heart failure models