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General peptide safety KPV, derived from a naturally occurring human peptide (alpha-MSH), has shown minimal side effects in research settings

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However, a significant increase in Bifidobacterium, Dialister , and Alistipes was reported ( Firmicutes (e.g., Ruminococcus and Blautia ), accompanied by an increase in Bacteroides, Lactobacillus , and Prevotella ( In conclusion, GLP-1 contributes to gut homeostasis and inflammation control through its modulatory effects on immunity, epithelial cell proliferation, and microbial composition ( Figure 1 )

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